Are you a parent of a child with autism, tensed about his future? Surely then you would know that raising a child with autism isn't an easy job.

According to the Centre for Disease Control and Prevention (CDC), 1 in 68 children are diagnosed to have Autism in U.S.A. However, in India roughly 40,000 children are diagnosed with autism and these numbers are sure to increase when the awareness level increases.

We, at NeuroGen Brain and Spine Institute, understand your worry, anxiety and the challenges that you face. We have the skills and infrastructure for altering your child's path leading to a more independent and fulfilling life. Our autism management program includes the latest advances in science and medicine - stem cell therapy for autism, which is combined with the various rehabilitation program like Applied behavior analysis (ABA), occupational therapy, speech therapy, physiotherapy, music therapy, dance therapy, art therapy, and much more; thus providing a comprehensive holistic, medical and rehabilitative treatment. Because at Neurogen, we just don't cure, but WE CARE!

OUR SUCCESS STORIES:

  • Child with Autism from London improves after stem cell therapy.
  • 6 Months goal achieved in 3 months in a child with autism.
  • He is almost like a normal child now.
  • 9 year old girl with Autism sings the national anthem and religious recitals in tune.

What is Autism?

Autism is a complex neuro - developmental disorder that typically appears during the first three years of life and which affects the functioning of certain areas of the brain. This in turn leads to compromised mental abilities such as understanding, perception, problem solving, speech, social interactions and behavior. Despite, normal physical appearance, their daily functioning is affected and they are dependent for daily activities. Children with autism have special needs that must be catered to differently.


What causes Autism?

Not long ago, the answer to that question would have been, 'we have no idea' However, research is now able to deliver such answers.

It is very important to understand that autism does not have a single known cause. Several theories have been put forth by researchers, doctors and scientists who say that

  • A structural or a functional damage to the nervous system can produce the condition of autism.
  • A change in the structure of a gene, often called as a mutation, may be responsible for abnormal brain development.
    Alternatively, non genetic factors such as certain perinatal complications such as maternal bleeding three months into pregnancy, presence of meconium in the amniotic fluid, insufficient nutrient intake during pregnancy etc.
  • Environmental factors (mercury poisoning, maternal stress, and lifestyle exposure to strong medications, toxins, infections or radiations)may also be a responsible for autism.

It is important however to realize that no particular individual or event can be held responsible for the child's diagnosis. Investing in the child's care and treatment, can go milestones in helping a child with autism.


What are the symptoms associated with autism?

Children do not 'outgrow' autism, but studies have shown that early intervention and diagnosis can lead to maximizing the independence and leading a better quality of life.

Listed below are some of the signs and symptoms of autism:

  • Difficulty using nonverbal behaviors such as eye-gaze, facial expressions, body postures, and gestures
  • Difficulty forming peer relationship
  • Difficulty starting or maintain a conversation
  • Delay or lack of development of spoken language
  • Repetitive behavior such as twirling or rocking
  • Excessive interest in objects or things, rather than people
  • Fleeting to avoiding eye contact
  • Failure to recognize or answer to their own name
  • Sensory issues like closing their ears to loud sound or do not like being touched, etc.
  • Short attention span, getting distracted easily
  • Self injurious behavior like head banging, biting oneself
  • Aggressive behavior towards others like biting, scratching, pulling others hair, throwing objects etc.
  • Attachment with irrelevant objects
  • Attachment with irrelevant objects
  • Appetite for non food and non nutritive items like chalk,paper,sand,paint, dirt (This phenomenon is called as pica and is generally seen in a moderate to severe form in children with autism.)

What are the treatment options available for autism?

As parents or caretakers, you may frantically look for all possible treatment options for your child. Autism management requires a multi-disciplinary treatment approach which includes not only medications but also therapies.


Occupational Therapy:

Occupational therapists focus on teaching activities of daily life like eating, bathing, grooming, dressing etc. They also conduct sensory integration therapy (SI) to reduce the sensory issues. Thus helping the child to lead an independent and meaningful life.


Psychological Intervention:

Bringing up a child with autism can be a challenging process. Children with autism experience anxiety, stress and fear leading to behavioral issues. Psychological intervention helps equip the parents and the child to deal with these problems.


Speech Therapy:

A speech and language pathologist works with children diagnosed with autism to help them understand communication and facilitating them to understand spoken language to give the child something to talk about. This increases the reason to communicate.


Medical Management:

Medication in autism is given to reduce certain moderate to severe symptoms such as mood swings, aggressive behavior, hyperactivity, etc. It is also advised to address the co –morbid conditions like OCD, depression, gastrointestinal problems, sleep disturbances, etc.

Though, autism is a very complex neurodevelopment disorder, various different studies have also tried understanding the basic reason as to why autism develops and what happens in the brain.


How stem cells work in autism

It is understood now, that the lack of oxygen supply to the brain and immune deregulation are the two key pathologies associated with autism. This in turn could be the cause of reduced functioning in this area. This coupled with an overall imbalance in the activity of the brain, is possibly responsible for the manifestations associated with autism.

Researchers and doctors are now looking at regenerative therapy using stem cells as potential therapy for children showing symptoms of autism. The lookout that stem cells possess the capability to multiply in many cells and form specialized cells different from the mother cell can help in repair of the damaged brain tissue forms the basis of this idea. Stem cells have the potential to repair the affected neural tissue at the molecular, structural and functional level. They are known to address the core of neuropathology of autism with the help of their unique paracrine regulatory functions that are capable of regulating cell differentiation, tissue and organ repair, and anti-inflammatory actions in the recipient.


The NeuroGen Outcome:-

At NeuroGen BSI we have successfully treated over 150 cases of Autism. We have published the world's first clinical study on the effect of stem cells in autism in 32 patients in the International Journal “Stem Cell International.” The path breaking results observed through this study has demonstrated the safety and efficacy of stem cell therapy.

Post stem cell therapy, our patients have shown remarkable improvements in various aspects. The behavior patterns that are observed in children with autism such as hyperactivity, engaging in stereotypical and repetitive motor mannerisms have decreased significantly. Immense improvements are also seen in their sensory aspects and motor activities. Several parents have also reported that the concentration and the attention span of their children are much better than before. The overall improvements that are seen in patients after stem cell therapy are:-

  • Reduction in self stimulatory behavior
  • Improvement in eye contact
  • Improvement in speech
  • Improvement in communication skills
  • Improvement in social interactions
  • Reduction in aggressive behavior

The clinical results seen with stem cell therapy in the autism patients treated to date at NeuroGen BSI show that 91% of these patients showed global improvement on Clinical Global Impression II (CGI-II) scale. Symptomatic improvements included 70% improvement in eye contact, 60% initiated socializing, 56% initiated social smile, 55% started maintaining peer relationships, self stimulating behavior decreased in 55%, 54% reduced echolalic speech,72% showed reduced hyperactivity, 66% showed reduced repetitive motor mannerisms and 48% showed reduced aggressive behavior.

These functional enhancements that have been seen in our patients can be co-related with the improvements in the brain metabolism as well that is observed in the PET-CT (Positron emission tomography- computerized tomography) scans of the patients.


Objective Radiological evidence of improvement after stem cell therapy in a case of autism


Pre Stem cell treatments PET CT scan show the blue areas that represent reduced brain activity due to the damage that occurs to the neural tissue in autism.


Post Stem Cell Treatment PET CT scan show the blue areas have reduced indicating that the damaged tissues have been repaired highlighting the positive effects of the stem cell therapy.

Stem Cell therapy using autologous bone marrow derived MNC's has shown significant clinical and objective radiological improvements in children with autism. It is simple, safe and effective treatment modality as it focuses on neurological repair. It gives a new life to these children and helps integrating them back into society.

Why does my child have Autism and what is the cause of Autism?

Parents of children with autism usually have common questions when they consult their developmental pediatrician or child psychiatrist:

  • How did our child develop autism?
  • My child was hale and healthy and had even started to speak a few words. Then, what happened suddenly?
  • So, is autism acquired?
  • Does it happen after the child is born?
  • Could it have been prevented?
  • Is it genetic?
  • Can the other children also have autism?
  • Has it come from "us", the parents?

The answer to this question long ago would have been “we have no idea.” There is no one cause of autism just as there is no one type of autism. Researchers are now however delivering the answers. Some combination of genetic, biological and environmental factors is believed to cause ASDs. Researchers are now however exploring several genes which are believed to contribute to the development of these disorders as well as several brain regions that have been linked to the disorders.

Is autism genetic?

Ans. Genetic factors are thought to be one of the most significant causes for autism spectrum disorders. Heritability was established, very early, by studying occurrence of autism in twins. Explaining occurrence of autism, purely on the basis of genetics is a very complex task. Though various molecular tools and analytical tools (such as linkage analyses, association analyses) have been tried to be used, but nothing very conclusive has emerged. Since, more than one gene has been implicated or found to be involved, a simple arithmetic or cause and effect, cannot be established. Researchers are also exploring the effects of genetic imprinting in which a gene’s expression is determined by which parent donates the gene copy. However, still there are no definitive answers to this question.

Will my other child also have autism?

Researchers from Aarhus University in Denmark have reported in a journal JAMA Pediatrics that children with an older brother or sister diagnosed with an autism spectrum disorder are more likely to be on the spectrum themselves. Siblings who shared the same mother and father had a 7.5 greater risk of having autism, whereas maternal half siblings had a 2.4 greater risk. Paternal half siblings didn’t have a statistically significant increase in risk. Hence it’s important that parents who already have a child diagnosed on the spectrum should be alert if they are thinking about another kid. They should inform the doctor about their family history before conceiving another child and should take precautionary measures such as taking prenatal folic acid and avoiding overexposure to toxins.

Is there a cure for autism?

There is no known 'cure' for autism. This does not mean, however, that nothing can be done for an individual with autism. However, there are medications and therapies that can help some people with ASD function better. For example, medication might help manage high energy levels, inability to focus, depression, or seizures and behaviour therapy can help parents manage the difficult behaviours in their child.

Can medications cure autism?

Until now there are no medicines available to cure autism. You should consult a developmental pediatrician or a psychiatrist if your child is has difficulty controlling aggression, is displaying self-injurious behaviors, throwing temper tantrums, repetitive behaviors or quickly changing moods. Medicines provide only symptomatic relief. However, treatment of symptoms is very important as it is the distressing symptoms that limit the quality of life of people with autism, their families and caregivers. Once the symptoms are controlled with medications, there is a better scope for benefit from multidisciplinary interventions like Occupational therapy, psychological therapy, speech therapy, vocational training, etc.

Which school should my child attend? Special or normal school?

A common dilemma that bothers several parents of children with autism is that of their child's formal education. Due to lack of clear cut guidelines, parents are unable to decide what type of schooling system is best for their child. Currently, the number of schools providing education to children with autism is severely limited as compared to the need.

Broadly speaking schools may be categorized into the following:

  • Mainstream or Regular,
  • Inclusive or Integrated,
  • Special services schools,
  • Home-schooling,
  • Residential schools or homes.

Children with autism generally have a very tough time with large groups, loud, stimulating settings, and poorly managed transitions. As the child grows older a typical classroom can be very challenging. The one to one is great when your child was is preschool or the first years of elementary school however it can become a serious liability in pre-adolescence and teenage years. That's not to say that a child with autism can't or won't excel in a typical setting. But for many children, small private schools and even colleges are a better bet than large public schools.

Is there any treatment or therapy available for my child?

As parents, you may frantically look for all possible treatment options for your child. Your search may give you several options which may further confuse you or create more doubts. With help from your developmental pediatrician, you may be able to identify the problems in your child and decide about the early intervention plan. Early identification has increased in importance, as many studies have found that children with ASD’s who receive services prior to 48 months of age make greater improvements than those who enter treatment programs after 48 months of age. Management in autism calls for a Multi-disciplinary holistic approach. A multi-disciplinary team consists of:

  • Clinical Psychologist
  • Occupational therapist
  • Speech and language pathologist
  • Dietician
  • Physiotherapist
  • Art, play, music, drama therapist
  • Each of the above professionals will target different aspects in the treatment of your child.

There are newer forms of therapies also which have been proven to be very effective like Stem Cell Therapy, Hyperbaric oxygen therapy (HBOT), etc.

Are there ethical concerns surrounding adult stem cell research and therapy?

Bone marrow transplantation has been used successfully for genetic disorders of blood, such as sickle cell anemia, thalessemia, as well as cancers such as leukemia. Since our therapy uses these very cell, which are harvested from the patient’s own body (autologous cells), there are no major ethical concerns. Ethical concerns are primarily on the use of embryonic stem cells (which we do not use).

Does the treatment have any side effects?

Stem cell therapy is minimally invasive and reasonably safe. None of our patients have shown any neurological deterioration so far in connection with the stem cell therapy itself. Some side effects, such as headache (spinal headache) lasting 3-4 days which is generally self limiting, neck/back pain, vomiting, some mild rash or pain at the site of bone marrow aspiration/stem cell injection may occur. However, like any other medical or surgical treatment unexpected complications are always a possibility. These complications may be related to the medicines given, the stem cell procedure, the anesthesia, and the rehabilitation or to any of the preexisting medical or neurological conditions.

How long will it take me to know that I have benefitted from the treatment?

Maximal improvements are seen around 3-6 months after the treatment. However, in many patients there are slow progressive improvements that continue for several months/years later. Most patients do show some immediate improvements also i.e. before the discharge, in some of their symptoms.

Is the transplantation of the stem cells done once or more than once?

The decision to do the therapy a second time is taken after seeing the progress/improvements after the first therapy. If the patients show some encouraging improvement, then the case is reviewed by the entire medical and rehabilitation team. Certain special imaging tests, such as PET CT Scan of the brain, would be repeated and then a second treatment may be recommended. This may be done anytime between 3-6 months of the first therapy.

Can other treatments be taken at the same time?

We will review what other medications the patient is already on. In most cases we do not discontinue any already going on treatment. However this is decided on a case by case basis. Please inform us about any medications you are taking beforehand.

What are the improvements expected after SCT?

At NeuroGen BSI we have successfully treated over 150 cases of Autism. We have published the world’s first clinical study of 32 patients in the International Journal “Stem Cell International”. The results published in this pathbreaking paper demonstrated that stem cells are safe and efficacious in autism.

Within the first three-six months, our patients show improvements in social relationships, emotional responsiveness, speech and language, communication, behavior patterns, reduced hyperactivity, repetitive motor mannerisms, sensory problems and attention and concerntration.

Our data is regularly published in various medical and scientific journal(available for reading on our website) . You are strongly advised to study these before proceeding with treatment.

How does stem cell therapy work?

The biological task of stem cells is to repair and regenerate damaged cells. Stem cell therapy exploits this function by administering these cells in high concentrations directly in and around the damaged tissue, where they advance its self healing and repair.

Are there ethical concerns surrounding adult stem cell research and therapy?

Bone marrow transplantation has been used successfully for genetic disorders of blood, such as sickle cell anemia, thalessemia, as well as cancers such as leukemia. Since our therapy uses these very cell, which are harvested from the patient’s own body (autologous cells), there are no major ethical concerns. Ethical concerns are primarily on the use of embryonic stem cells (which we do not use).

Is the treatment painful?

The therapy is done under local anesthesia and a mild sedation. There is no significant pain or discomfort during or after the procedure.

Does the treatment have any side effects?

Stem cell therapy is minimally invasive and reasonably safe. None of our patients have shown any neurological deterioration so far in connection with the stem cell therapy itself. Some side effects, such as headache (spinal headache) lasting 3-4 days which is generally self limiting, neck/back pain, vomiting, some mild rash or pain at the site of bone marrow aspiration/stem cell injection may occur. However, like any other medical or surgical treatment unexpected complications are always a possibility. These complications may be related to the medicines given, the stem cell procedure, the anesthesia, and the rehabilitation or to any of the preexisting medical or neurological conditions.

How long will it take me to know that I have benefitted from the treatment?

Maximal improvements are seen around 3-6 months after the treatment. However, in many patients there are slow progressive improvements that continue for several months/years later. Most patients do show some immediate improvements also i.e. before the discharge, in some of their symptoms.

Is the transplantation of the stem cells done once or more than once?

The decision to do the therapy a second time is taken after seeing the progress/improvements after the first therapy. If the patients show some encouraging improvement, then the case is reviewed by the entire medical and rehabilitation team and a second treatment may be recommended. This may be done anytime between 3-6 months of the first therapy.

Can other treatments be taken at the same time?

We will review what other medications the patient is already on. In most cases we do not discontinue any already going on treatment. Please inform us about any medications you are taking beforehand.

6 months goals achieved In 3 months in a Child with Autism

4.8 years male child born of full term normal delivery with 3.7 Kgs birth weight, history of Neonatal jaundice on 2nd day of birth and treated with phototherapy. He achieved all his motor milestones age appropriately and monosyllable speech at one and a half years of age. But unlike other kids he was very hyperactive, he had poor eye contact, delayed response and delayed speech hence at the age 2 years parents consulted doctors and he was diagnosed as a case of Mild Autism. He was on regular Speech therapy and Occupational therapy since then. It was really difficult for the parents to take him anywhere.

He was brought to NeuroGen Brain and spine Institute, following which all the assessments were done and it was found that his main concerns as reported by parents were Hyperactivity, poor eye contact, poor attention and concentration, poor imitation, poor sitting tolerance, motor mannerisms like fidgeting with fingers, temper tantrums, pushing kids in school. On evaluation it was found that he was auditory hypersensitive (used to get irritated with cooker whistle, washing machine), Vestibular and Tactile Hyposensitive. Functionally he could eat finger foods and use to spill other daily food articles, while bathing he could only pour water, he could not do dressing independently and required maximum assistance, he was not toilet trained. He was assessed on Functional Independence Measure and he Scored 63 and on ISAA (Indian Scale for Assessment of Autism) he scored 106 (70%).

PET scan, MRI Brain and EEG was done as standard Investigation and was considered for Stem Cell Therapy following which he received Occupational therapy , Speech Therapy and Psychological Session in a play way for 4 days after Stem Cell Therapy. At the end of 1 week the following improvements were seen : Repetitive hand movements had decreased, hyperactivity slightly reduced, attempts to listen to auditory stimuli and follows commands, sitting tolerance and attention span slightly Improved after 3 days, imitation improved and Vocalization on demand initiated.

After 3 months he came for his 1st follow up as a routine protocol and it was found that he had drastic improvements like his finger fidgeting had reduced by 75%,his understanding had improved he could now get apple, banana, potato when his mother use to give him commands, his repetition of words had reduced and now he could voluntarily say few words like chips, now he socially interacts and wants to go for group therapy sessions and also likes to play with other kids in the garden, his pushing behavior has completely stopped, unusual noise have reduced, fear of cooker whistle has completely veined off and now if tries to tolerate the noise by slowly opening his ears,. Functionally he could now eat food on his own (could break dosa pieces dip it in chutney and eat). He could gargle while brushing.

His school teacher reported that his eye contact has improved, he listens to her, his sitting tolerance has improved and he could tolerate group therapy session for 15 minutes. 'He achieved his 6 months goal in 3 months '. On assessment it was found that his ISAA scored reduced from 106 to 88 (70% to 60%), his FIM Score increased from 63 to 69.


Autistic child from London improves after stem cell therapy

9 years old Male child from London born on 34th week Normal delivery and prolonged labour, did not cry immediately after birth and having 2.5 kgs birth weight thereby kept under observation for 5 days. He had history of normal milestone development, also speech developed and spoke words like 'pasta', 'biscuit', 'juice'. He was a bright kid and he had good grasping power. But later at 2 and a half years he regressed and parents started noticing that he had poor social interaction and he started regressing with speech slowly. Hence consulted psychiatrist and diagnosed as a case of Autism at the age of 4 and a half years. Since then he was going to a normal school with a shadow teacher, later at 6 and a half years he was sent to a special school and received regular Occupational Therapy and Speech Therapy once a week . His mother was well aware about his problems and always tried all possible treatment options for him.

Later once while browsing in the internet; she came across Stem Cell Therapy as a treatment option for Autism. Hence she called NeuroGen Brain and Spine Institute to know more about Stem Cell Therapy.

They came to India in last week of September. All the routine investigations were done as a prerequisite. On 30th spetember, 2013 he was admitted and was completely assessed. The chief complains as presented by the mother during the time of evaluation were as follows : Poor social interaction, fleeting eye contact, inappropriate emotional responses like irrelevant laughing and crying without any reason, motor mannerisms like finger fidgeting, rocking etc. smelling objects, presence of unusual noises, fearful of loud noises, weak fine motor skills, poor – fair perceptual and cognitive skills.

On evaluation it was found that he was Tactile, Vestibular, Proprioceptive and Olfactory Hyposensitive. Auditory Hypersensitive.

Functionally he was independent for almost all his Activities of Daily living but the main concern of the mother which she emphasized even during the evaluation was, he had difficulty in buttoning, zipping and lacing. His functional independence Measure Score was 74.

On Assessment he scored 117 (70%) on ISAA {Indian Scale for Assessment of Autism} and 34 on Childhood Assessment Rating Scale.

He underwent Stem Cell Therapy on 1st of October following which they decided to stay in India and do regular rehabilitation for 1 month post stem cell therapy. Hence he was given regular Occupational Therapy, Speech Therapy and Psychological Session for 6 days a week for 1 month.

On the final day of therapy the following improvements were reported by the parents and were observed by the professionals:


Improvement in Perceptual and Cognitive Skills :

  • Eye contact was more meaningful.
  • Overall attention and concentration improved especially while speaking to him.
  • Overall awareness had increased.
  • He could swing on his own, which the parents were trying to teach him since 5 years.
  • He can point out his body parts like eyes, ears and nose.
  • He identifies A – Z and can place it in order in the board.
  • He identifies shapes and can insert in the 3D box.
  • He can now identify red and yellow colour, also he can do sequencing of beads and flower links.
  • He can identify red and yellow colour with shapes.

    • Improvement in Sensory Problems:

      • Earlier he would pick up his T shirt and ask his parents to scratch his stomach which has completely stopped now.
      • His auditory hypersensitivity has reduced considerably. He could tolerate the sound of a baby crying in the room, also people talking around him. ear closing was minimal during the session and outdoors.
      • Motor mannerisms have reduced in public places.

        • Improvement in Social Interaction and Communication:

          • He can now play ball throwing and catching game in a group with his parents and therapist.
          • Previously when they were on Skype with his relatives he needed to be forced to interact with their relatives but now he points towards them and kisses them.
          • He uses to grab his parent's attention by vocalizing.
          • He now tries to convey his needs by pointing accompanied by making noise.
          • He had spontaneous vocalization, he says |a|on demand.

            • Improvements in Activities of Daily Living:

              • He can now Button his shirt; also he buttoned his mother's Shirt.
              • He can now cross and an initial knot for tying shoe lace.
              • His fine motor skills have improved.

              The parent's were very happy with the improvements and they are in regular contact with all the professionals at NeuroGen Brain and Spine Institute through email.

              Recently they sent a mail saying,” he is doing well (some days more, some less). I am following all your commands :-)... Zipping up is complete since we arrived. 5 colours threading and sequencing is also complete. Buttoning is good. Making straight lines vertically and horizontally without a ruler l He is holding the pen firmly and trying to write the letter O. He is also trying to colour inside the shapes without a play dough.. It is ok for now, still to be perfect. I am struggling to teach him to tie the shoes lace, but I am taking it easy. Slowly we'll get there. I keep taking him to roller-skating (he skates so well). Today was his first ice-skating lesson and he did quite well. Tomorrow I am taking him to swimming lesson, in the mean time I am trying to organize different play groups (art and craft etc).”


              'He is almost like a Normal Child'

              17 years old born of full term C- section delivery cried immediately after birth, with 7.5 pounds birth weight. He had history of delayed milestones. Also he had history of frequent falls while walking between 2 and 7 years of age. He was assessed at 6 years of age and was termed to be having borderline intelligence level with 72 IQ.

              He underwent regular occupational therapy and speech therapy since the time of diagnosis. In the year 2011, his family came to know about Stem Cell Therapy as a treatment option for Autism with Mental Retardation. And he was assessed thoroughly by all professionals. The main concerns as stated by his grandmother being his primary care taker were poor eye contact, blurred speech, drooling, poor fine motor activity, poor problem solving, delayed reaction time, he was hypersensitive to sound. On evaluation it was found that he had generalized hypotonia, poor standing balance, incoordination. But also unlike other kids he had a savant ability that he could tell the day of any date. For example if he was asked tell me on 22nd June, 2015 which day it will be, he could answer within few minutes that it will be Monday.

              He scored 85 on Indian Scale For Assessment Of Autism {ISAA} , 15 on CARS { Childhood Autism Rating Scale}.

              Functionally he was independent for all his Activities of Daily Living 117.

              When he came for 1st follow the following improvements were seen:

              Improvement In cognitive and perceptual skills:

              • He does things willingly, earlier he required continuous prompts.
              • He could give his opinion in family matters.
              • His grasping power has improved.

              Improvement in Fine Motor Skills:

              • He can pick up small objects with fingers.
              • His balance also improved.
              • On assessment his ISAA score reduced from 84 to 75.
              • He was advised to continue all the exercises and treatment protocol.
              • Later he came for his next follow up after 2 years of Stem Cell Therapy. During which his grandmother reported that he had many improvements after 1 year of stem cell therapy. Also the statement given by grandmother was, “he is as good as a normal child”.
              • He presented with following improvements after 1 year of stem cell therapy:

              Improvement In Oro – motor skills:

              • His drooling has reduced considerably.
              • His clarity of speech has improved.

              Improvement In Cognitive, perceptual and Social Skills:

              • He behaves more mature.
              • He now understands the importance of exercises and thereby does it on his own.
              • He maintains eye contact with all the guests who come home.
              • His vocabulary has improved, now he knows capital of all countries.
              • He can now fill the bank slip on his own and also go to the bank and deposit money.
              • He can now translate words from Marathi to English language.
              • He can now relate people and understands everything.
              • He can now argue with his grandmother.
              • He can imitate.
              • He makes paper bags and sell it to a medical store and monthly earns around Rs 600/-
              • He has been offered to work as an assistant in his therapy centre for which he will get stipend.

              Improvement in Fine Motor Activities:

              • He can now button his shirt and do zipping.
              • While making paper bags, he makes with lot of precision.

              Improvement In sensory Issues, Balance and Co – Ordination:

              • Hypersensitivity to sound has reduced. Now he only gets scared of crackers.
              • His incoordination has reduced.
              • The grandmother at the time of follow up just mentioned that, “he is almost like a normal child”.
              • On assessment his ISAA Score reduced from 75 to 69. (From Mild Autism to No Autism)