- About NeuroGen
- About Stem Cell Therapy
- Virtual OPD
- Scientific Publications
- Accreditation & Awards
- International Patients
There are times in human history when quantum leaps occur in our thinking and approach towards the various issues we face as a race. The world of medicine and healthcare has witnessed one such landmark in the past decade. This is the revolutionary field of stem cell therapy that was awarded the prestigious Nobel Prize in Physiology or Medicine in the year 2012. This Nobel Prize was awarded jointly to British scientist Sir John B. Gurdon and Japanese stem cell researcher Shinya Yamanaka for the discovery that mature cells can be reprogrammed to become pluripotent.
Regenerative medicine is a game-changing and rapidly evolving field of modern medicine. It is focused at repair, restoration and replacement of damaged tissues by a safe and effective administration of living cells either in solitude or in combination with specially engineered materials. Regenerative medicine itself isn’t new; the first bone marrow and organ transplants were carried out decades ago. Technological advances in developmental and cell biology, immunology, and other fields have ushered in a new era of therapeutic strategies to refine existing regenerative therapies and develop novel ones. These therapies are beneficial for a multitude of disorders that today are beyond repair. This includes neurological disorders like autism, cerebral palsy, muscular dystrophy, spinal cord injury, brain stroke, traumatic brain injury, etc. Current research in the field of regenerative medicine utilize stem cells to create functional tissues to regenerate damaged or injured organs and tissues.
A cell is the basic structural and functional unit of all living organisms. Cells have evolved over billions of years and are responsible for all the metabolic activities of the body. They have adapted to a wide array of functional roles and environments. All cells originate or "stem" from simpler and premature cells that have not specialized or differentiated yet. These unspecialized cells are called stem cells. Stem cells are one of the building blocks of the ever-evolving field of Regenerative Medicine. They have fascinated clinicians and scientists for over a century. They can be defined as undifferentiated cells that have the remarkable property of giving rise to different cell types. All multicellular organisms rely on stem cells to develop from a single cell to a fully mature adult. Stem cells are also responsible for replacing or replenishing specialized cells in the body that are damaged or worn out. Stem cells are now considered to be a miracle of modern medicine and have given rise to a new era of therapeutic strategies. A variety of stem cells are being used from diverse sources or origins.
Stem cells are characterized by two unique and distinct properties of self-renewal and differentiation into various cell types. They have the remarkable potential to divide indefinitely, producing a population of identical cells. Additionally, in many tissues they serve as a sort of internal repair mechanism, dividing essentially without limitations to replenish other cells. Stem cells achieve their reparative functions through the following mechanisms:
A) They can Multiply infinitely
B) Stem cells can convert themselves into other cell types
C) Stem cells release positive chemicals
D) Stem cells improve blood supply
Based on their origin, stem cells can be broadly classified into the following three categories:
The word potency is taken from the Latin term "potens" which means "having power". The capacity or "power" of stem cells to differentiate into specialized cell types and further give rise to any mature cell type is called potency. Based on their potency, there exists a hierarchy in the stem cell compartment.
At NeuroGen, we utilize adult stem cells obtained from the patient’s own body to treat incurable disorders like Autism, Cerebral Palsy, Muscular Dystrophy, Mental Retardation, Spinal Cord Injury, Traumatic Brain Injury, Ataxia’s, etc. We offer a unique and holistic combination of stem cell therapy and neurorehabilitation in our treatment program. We believe that a multi-disciplinary approach is the key to not only treat patients with these conditions, but to also restore health and vitality. The Stem cell therapy we provide is minimally invasive, effective and 100% safe since it utilizes autologous adult stem cells. Our neurorehabilitation techniques involve an intensive regiment administered by experienced professionals from various fields which including physiotherapy, occupational therapy, speech therapy, special education, psychology, etc. All these facilities are housed within our eleven storied multispecialty centre, along with provisions for special consultations.
The stem cell transplantation procedure at NeuroGen is minimally invasive and requires no major surgery or incision. The procedure is carried in the following three steps:
The stem cells are injected with the help of a spinal needle in the spinal canal through a lumbar puncture. This is the intrathecal route of administration and it helps in overcoming the blood brain barrier. The lumbar puncture helps the stem cells to migrate directly to the damaged brain areas and regenerate neurons. As opposed to this, cells injected intravenously, must go through various organs such as liver, lung, etc. Due to this, the number of cells finally reaching the target area would be far less than required.
The stem cell therapy at NeuroGen is followed by an intensive neurorehabilitation process which includes physiotherapy, occupational therapy, aquatic therapy, creative visualization, yoga therapy, counseling and specialized diets.(We strongly emphasize that stem cell therapy should be followed by a proper rehabilitation regime to gain a proper response. The rehabilitation therapies enable the mobilization of stem cells and aid in the regenerative and reparative process. This holistic approach helps the patients to lead a better quality of life and contributes to their overall wellbeing.Our entire treatment program of stem cell therapy combined with neurorehabilitaion is referred to as Neuro Regenerative Rehabilitation Therapy (NRRT).
Adult stem cell therapy is a completely safe form of treatment. At Neurogen BSI and in all the available publications internationally and nationally, there have been no cases of serious adverse events or neurological deterioration due to stem cell therapy. Minor reversible symptomatic procedure related problems occasionally do occur but these are completely treatable with no long lasting effects.
Rapid progress in the field of biotechnology has introduced a myriad of pressing ethical issues associated with stem cell research. Worldwide and particularly in Asian countries, where stem cell therapy is more advanced, the ethical basis of utilizing stem cell therapy as a treatment modality is based on the Declaration of Helsinki (DoH) on the ethical principles for medical research involving human subjects. This Declaration of Helsinki is a set of ethical principles regarding human experimentation developed for the medical fraternity and is drafted by the World Medical Association (WMA). It is widely regarded as the cornerstone document on the bioethics of human research. The following is an excerpt from the Declaration of Helsinki:
"In the treatment of an individual patient, where proven interventions do not exist or other known interventions have been ineffective, the physician, after seeking expert advice, with informed consent from the patient or a legally authorised representative, may use an unproven intervention if in the physician's judgement it offers hope of saving life, re-establishing health or alleviating suffering. This intervention should subsequently be made the object of research, designed to evaluate its safety and efficacy. In all cases, new information must be recorded and, where appropriate, made publicly available."
Hence, as per the Declaration of Helsinki, stem cell therapy can be utilized for conditions which have no other treatments available. At NeuroGen Brain and Spine Institute, we strictly adhere to and abide by the above stated Declaration.